Cambridge Healthtech Institute’s

(Re)Discovering Protein Expression Platforms

January 13, 2025

How best to express? The demand for high-quality recombinant proteins has never been greater. Thus, selecting a host expression platform is the crucial step in recombinant protein production. Additionally, the biological characteristics of the requested recombinant protein and, to a lesser extent, the planned downstream applications dictate this selection, as well. Finally, choosing the expression platform that is the most familiar, without regard to its suitability for the desired protein of interest may not be optimal. Using an inappropriate system can have serious implications for the expression levels, solubility, and functionality of the recombinant protein required, making the choice of host platform a first essential step in the optimization process. Cambridge Healthtech Institute’s (Re)Discovering Expression Platforms symposium convenes protein expression specialists who share their experiences, strategies, selection process, and success.

Coverage will include, but is not limited to:

Hosts

Mammalian
Insect
Bacterial
Yeast
Cell-Free Systems
Plants

Proteins

Intracellular
Secreted
Membrane Protein
Difficult to Express

Single- or Multi-domain Protein
Protein Complexes/Co-Expression

Host Selection Strategies

Matching Host to Protein of Choice
Stable Expression vs. Transient Expression
Increasing Speed and Lowering Cost

Cloning Strategies
Re‐engineering Existing Systems for Better Performance
Automation for Higher Throughput Expression and Purification
Development/Standardization of Analytical Assays to Determine Identity, Purity, and Biological Activity
Case Studies

The deadline for priority consideration is June 28, 2024.

All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute’s policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.

Opportunities for Participation: