Cambridge Healthtech Institute Training Seminars offer real-life case studies, problems encountered and solutions applied, along with extensive coverage of the academic theory and background. Each Training Seminar offers a mix of formal lecture and interactive discussions and activities to maximize the learning experience. These Training Seminars are led by experienced instructors who will focus on content applicable to your current research and provide important guidance for those new to their fields.

MONDAY, JANUARY 20 - TUESDAY, JANUARY 21

TS8A: Protein Aggregation and Formulation Optimization

Aqua 310A

DAY 1: MONDAY

9:00 am - 6:00 pm Seminar Sessions

12:45 - 1:30 pm Lunch Provided
6:00 - 7:15 pm Welcome Reception in the Exhibit Hall with Poster Viewing

DAY 2: TUESDAY

8:45 am - 12:30 pm Seminar Sessions

Exhibit Hall Refreshment Breaks also provided.

Instructors:

Thomas Laue, PhD, Professor Emeritus, Biochemistry, and Molecular Biology; Director, Biomolecular Interaction Technologies Center (BITC), University of New Hampshire

Kevin Mattison, PhD, Principal Scientist, Malvern Pananalytical, Inc.

Matthew Brown, PhD, Applications Manager, Bioscience, Malvern PANalytical, Inc.

Molecular interactions are central to protein discovery and development and formulation development. This training seminar allows a fundamental, but very practical, understanding of protein interactions, solution behavior, aggregate formation and its application to formulation optimization. Building on a review of central energy concepts, the framework allows a deeper understanding of protein structural stability, interactions with small molecules, surfaces, itself, other proteins, and other macromolecules. A deeper insight is afforded into the binding, solubility, viscosity, and detection and characterization of protein aggregates.

Agenda:

• Current Challenges
  

• Understanding Protein Interactions
• Protein folding and solution stability
• Protein interactions, cooperative interactions
• Prediction of protein solution behavior
• Protein Aggregation and Viscosity
• Proteins at high concentrations
• Describing protein aggregates
• Understanding the impact on formulation stability
• Detection and Characterization of Protein Aggregates
• Tools for detection and characterization of protein interactions
• Tools for the prediction of aggregation
• What are the key analytical challenges in characterizing protein aggregates?
• Analytical tools for prediction and quantification of protein aggregates
• Impact of Aggregates on Formulation Development
• Immunogenicity
• Formulation optimization
• Particle Interactions and Case Studies

Who Should Attend:

This seminar is useful for senior scientists, protein chemists, structural chemists, technicians, and post-docs who work with proteins. It will benefit anyone involved in the development or use of binding assays, anyone characterizing protein structure and stability, protein formulations, and anyone focused on protein biological functions.

Instructors:

Thomas Laue, PhD, Professor Emeritus, Biochemistry and Molecular Biology; Director, Biomolecular Interaction Technologies Center (BITC), University of New Hampshire

Tom Laue is the emeritus Carpenter Professor of Molecular, Cellular and Biomedical Sciences, and professor of Material Sciences at the University of New Hampshire. He is the Director Emeritus of the Center to Advance Molecular Interaction Science and the Biomolecular Interaction Technologies Center. He received his bachelor’s degree in Natural Sciences from the Johns Hopkins University in 1971 and his PhD in Biophysics and Biochemistry from the University of Connecticut in 1981. His post-doctoral studies were conducted at the University of Oklahoma. Between 1969 and 1975, he worked as a technician in the deep space program of NASA. He joined the University of New Hampshire in 1984 as an Assistant Professor, where he taught both undergraduate and graduate courses in biochemistry and biophysics. His research focused on the development of instrumentation and methods for examining macromolecular interactions. These instruments provide unique insights into these interactions and resulted in extensive collaborations with both academic and industrial labs. Tom has over 120 publications, serves on several editorial boards, and gives over one hundred lectures, seminars and workshops a year.

Kevin Mattison, PhD, Principal Scientist Bioanalytics, Malvern PANalytical

Dr. Mattison completed his doctorate in biological chemistry at Purdue University, where he studied the effects of polyelectrolyte additives on the stability and activity of transport proteins and enzymes. From there he joined Protein Solutions as the Applications Development and Technical Support Manager and was instrumental in helping to drive the adoption of sub-micron light scattering techniques from esoteric technologies into mainstream laboratory tools. In 2002 Dr. Mattison joined Malvern Instruments, where he served as Applications Manager, Product Manager, and Director of Customer Support, prior to assuming his current position as Principal Scientist – Bioanalytics in the Strategic Technology Development Group.

Matthew Brown PhD, Applications Manager, Bioscience, Malvern PANalytical

Matt Brown completed his PhD at the University of London and followed this with Postdoctoral Fellowships at Harvard Medical School, in Boston, USA. Prior to joining Malvern Panalytical, Matt worked in the biopharmaceutical sector, employing a range of biophysical and biochemical methods to support bioprocess development and commercial manufacturing operations. Currently, Matt is the Bioscience Applications Manager for the US, specializing in the Biopharmaceutical sector.

WHAT IS A TRAINING SEMINAR?

Each CHI Training Seminar offers 1.5 days of instruction, refreshment breaks, exhibit hall functions, and lunch for all registered attendees on the full day of the class. Each person registered for the Training Seminar will be provided with a hard copy handbook for the Training Seminar in which they are registered. A limited number of additional handbooks may be available for other delegates. CHI encourages track hopping between conference programs, and we ask that Training Seminars not be disturbed once they have begun. We ask that attendees commit to attending the entire 1.5-day training, and not engage in track hopping once the class has started.